WP-TZ2

For in-vitro laboratory research use only. Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures. Sold to qualified researchers aged 21+.

What WP-TZ2 is

Tirzepatide (LY3298176) is a 39-amino-acid synthetic peptide based on the native GIP sequence, modified to act as a dual agonist of the GIP and GLP-1 receptors. Two α-aminoisobutyric acid (Aib) substitutions confer resistance to DPP-4 cleavage, and a C20 fatty-diacid moiety supports albumin binding.

Mechanism described in the literature

Tirzepatide is characterized in the literature as an imbalanced, biased dual agonist: it binds GIPR with affinity comparable to native GIP while engaging GLP-1R with lower affinity and reduced β-arrestin recruitment relative to native GLP-1. This bias profile is a frequent subject of signaling and receptor-trafficking studies.

Research areas

• Dual incretin receptor pharmacology and signaling bias
• β-arrestin recruitment and receptor internalization
• Islet insulin secretion models
• Energy balance and adiposity models
• Comparative studies against selective GLP-1R agonists

Specifications

Sizes and packs

Single vial at list price · 3-Pack = Buy 2, Get 1 Free (exactly 2× list) · 10-Vial Lab Kit = 25% off list. Select the size and pack above; the price updates.

Handling and storage

Store sealed vials at -20 °C, protected from light and moisture. 2–8 °C is acceptable for short periods such as transit and receiving. Allow a cold vial to reach room temperature before opening to avoid condensation on the lyophilized cake.

Vials ship sealed, cushioned and with a desiccant pack in plain packaging. Each vial is labeled with the product code, net content and the research-use designation. A packing slip lists the product codes and quantities ordered.

Frequently asked questions

Who can order?
Qualified researchers aged 21+ purchasing for in-vitro laboratory research. You confirm this at site entry and again at checkout.

When does it ship?
Orders confirmed by 2 PM CT ship the same business day by USPS Priority Mail (1–3 business days). Free shipping on orders over $149. Tracking is emailed when the carrier scans the label.

Can I return it?
All sales are final. Items that arrive damaged or incorrect are replaced when reported with photos within 72 hours of delivery — see Shipping & Returns.

References

1. Coskun T, Sloop KW, Loghin C, et al.. LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept. Molecular Metabolism 2018. doi:10.1016/j.molmet.2018.09.009
2. Willard FS, Douros JD, Gabe MBN, et al.. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI Insight 2020. doi:10.1172/jci.insight.140532
3. Jastreboff AM, Aronne LJ, Ahmad NN, et al.. Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine 2022. doi:10.1056/NEJMoa2206038

This overview summarizes published literature about the reference compound and is provided for research context only. It is not a description of the properties, effects or uses of this product, which is supplied strictly for in-vitro laboratory research by qualified researchers. Nothing on this page is an instruction for preparation or use.

For in-vitro laboratory research use only. Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures. Sold to qualified researchers aged 21+.