WP-TB4

For in-vitro laboratory research use only. Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures. Sold to qualified researchers aged 21+.

What WP-TB4 is

TB-500 is the research designation for synthetic thymosin beta-4 (Tβ4), a naturally occurring 43-amino-acid, N-terminally acetylated peptide that is the major actin-sequestering molecule in most mammalian cells. This product is the full-length sequence (Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES).

Mechanism described in the literature

Tβ4 binds monomeric G-actin, regulating the pool available for filament assembly and thereby cell motility. The central actin-binding motif (LKKTET) is required for its migration-promoting activity. Studies describe Tβ4 activating integrin-linked kinase (ILK) and Akt in cardiac cells, promoting endothelial and keratinocyte migration, and influencing inflammatory signaling in wound models.

Research areas

• Actin dynamics and cell motility
• Dermal wound-healing models
• Cardiac cell migration and ILK/Akt signaling
• Corneal epithelium models
• Anti-inflammatory signaling in injury models

Specifications

Sizes and packs

Single vial at list price · 3-Pack = Buy 2, Get 1 Free (exactly 2× list) · 10-Vial Lab Kit = 25% off list. Select the size and pack above; the price updates.

Handling and storage

Store sealed vials at -20 °C, protected from light and moisture. 2–8 °C is acceptable for short periods such as transit and receiving. Allow a cold vial to reach room temperature before opening to avoid condensation on the lyophilized cake.

Vials ship sealed, cushioned and with a desiccant pack in plain packaging. Each vial is labeled with the product code, net content and the research-use designation. A packing slip lists the product codes and quantities ordered.

Frequently asked questions

Who can order?
Qualified researchers aged 21+ purchasing for in-vitro laboratory research. You confirm this at site entry and again at checkout.

When does it ship?
Orders confirmed by 2 PM CT ship the same business day by USPS Priority Mail (1–3 business days). Free shipping on orders over $149. Tracking is emailed when the carrier scans the label.

Can I return it?
All sales are final. Items that arrive damaged or incorrect are replaced when reported with photos within 72 hours of delivery — see Shipping & Returns.

References

1. Goldstein AL, Hannappel E, Kleinman HK. Thymosin β4: actin-sequestering protein moonlights to repair injured tissues. Trends in Molecular Medicine 2005. doi:10.1016/j.molmed.2005.08.004
2. Malinda KM, Sidhu GS, Mani H, et al.. Thymosin β4 accelerates wound healing. Journal of Investigative Dermatology 1999. doi:10.1046/j.1523-1747.1999.00708.x
3. Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 2004. doi:10.1038/nature03000

This overview summarizes published literature about the reference compound and is provided for research context only. It is not a description of the properties, effects or uses of this product, which is supplied strictly for in-vitro laboratory research by qualified researchers. Nothing on this page is an instruction for preparation or use.

For in-vitro laboratory research use only. Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures. Sold to qualified researchers aged 21+.