WP-5AQ

For in-vitro laboratory research use only. Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures. Sold to qualified researchers aged 21+.

What WP-5AQ is

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It is not a peptide; it is supplied here because NNMT biology sits alongside the NAD+ and energy-metabolism research served by the rest of the catalog.

Mechanism described in the literature

NNMT methylates nicotinamide to 1-methylnicotinamide using S-adenosylmethionine, draining both the NAD+ salvage pool and the cellular methyl pool. 5-Amino-1MQ is a membrane-permeable, selective NNMT inhibitor; in adipocyte and diet-induced-obesity mouse studies, inhibition was associated with increased intracellular NAD+ and SAM and reduced adipocyte lipogenesis.

Research areas

• NNMT enzymology and inhibitor structure–activity
• NAD+ salvage pathway and methyl-donor balance
• Adipocyte metabolism in vitro
• Diet-induced obesity rodent models
• Cancer-cell metabolism models with high NNMT expression

Specifications

Sizes and packs

Single vial at list price · 3-Pack = Buy 2, Get 1 Free (exactly 2× list) · 10-Vial Lab Kit = 25% off list. Select the size and pack above; the price updates.

Handling and storage

Store sealed vials at -20 °C, protected from light and moisture. 2–8 °C is acceptable for short periods such as transit and receiving. Allow a cold vial to reach room temperature before opening to avoid condensation on the lyophilized cake.

Vials ship sealed, cushioned and with a desiccant pack in plain packaging. Each vial is labeled with the product code, net content and the research-use designation. A packing slip lists the product codes and quantities ordered.

Frequently asked questions

Who can order?
Qualified researchers aged 21+ purchasing for in-vitro laboratory research. You confirm this at site entry and again at checkout.

When does it ship?
Orders confirmed by 2 PM CT ship the same business day by USPS Priority Mail (1–3 business days). Free shipping on orders over $149. Tracking is emailed when the carrier scans the label.

Can I return it?
All sales are final. Items that arrive damaged or incorrect are replaced when reported with photos within 72 hours of delivery — see Shipping & Returns.

References

1. Neelakantan H, Vance V, Wetzel MD, et al.. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology 2018. doi:10.1016/j.bcp.2017.11.007
2. Neelakantan H, Wang HY, Vance V, et al.. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. Journal of Medicinal Chemistry 2017. doi:10.1021/acs.jmedchem.7b00389

This overview summarizes published literature about the reference compound and is provided for research context only. It is not a description of the properties, effects or uses of this product, which is supplied strictly for in-vitro laboratory research by qualified researchers. Nothing on this page is an instruction for preparation or use.

For in-vitro laboratory research use only. Not for human or veterinary use. Not for use in diagnostic or therapeutic procedures. Sold to qualified researchers aged 21+.